Showing posts with label rectal microbicide. Show all posts
Showing posts with label rectal microbicide. Show all posts

Wednesday, October 2, 2013

Advocates Applaud Launch of MTN-017, World’s First Phase II Rectal Microbicide Study

[IRMA press release]
 
Trial Design Significantly Enhanced By Strong Community Input

October 2, 2013 – IRMA applauds the launch of the world’s first-ever Phase II rectal microbicide trial. The Microbicide Trial Network’s study, called MTN-017, will test a reduced glycerin formulation of tenofovir gel applied rectally. Volunteers consisting of gay men, other men who have sex with men, and transgender women will participate in the study at sites in the United States and in Thailand, South Africa, and Peru.

“Today feels like every holiday imaginable rolled into one,” said Jim Pickett, chair of International Rectal Microbicide Advocates (IRMA.) “The launch of the MTN-017 study is a milestone long in the making and marks a giant leap forward in the development of safe, effective, acceptable, and accessible products that could be used to prevent HIV during anal intercourse.”

IRMA is pleased to have participated in an intensive community input process with the Microbicide Trials Network that included in-person consultations with advocates and key stakeholders in Thailand, South Africa, Peru and the United States. “The dreams and desires of many men, women, and transgender individuals the world over can be heard loud and clear in the design of the MTN-017 trial. This deep collaboration between scientists and community members is key to the success of this trial and to the rectal microbicide field in general,” said Pickett.

When microbicides were first imagined, they were “vagina-centric.” While many embraced the notion of creating vaginal products women could control, the majority of the HIV/AIDS community— scientists and advocates alike— dismissed the possibility of developing rectal microbicides for use during anal intercourse as an HIV prevention method. It was not considered feasible and the pursuit was seen as hopeless, even laughable. At best, the rectal microbicide field would consist of testing vaginal microbicides for rectal safety, because these products would undoubtedly end up in the rectum despite their intended destination.

IRMA thanks the visionary scientists, advocates and funders like the U.S. National Institutes of Health who bucked prevailing “wisdom” and have remained steadfast in their commitment to developing new HIV prevention methods for use during anal intercourse.

“I feel like we are taking two giant leaps forward today. One in the fight against HIV, and the other in the fight against ignorance and small thinking,” said Pickett.

# # # #

International Rectal Microbicide Advocates (IRMA) is a global network, housed at AIDS Foundation of Chicago, comprised of more than 1,200 advocates, scientists, policy makers and funders focused on rectal microbicide research and advocacy and related issues such as access to safe, condom-compatible lubricants.

Learn more about the MTN-017 study here.

Watch this video “The Rectal Revolution is Here: An introduction to rectal microbicide clinical trials” in English, Spanish, or Thai.

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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,100 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

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Sunday, September 8, 2013

Sept 10 at #USCA2013 - Everything You Need to Know About #Anal Health

This Tuesday, September 10 at the United States Conference on AIDS in New Orleans join IRMA and friends from 4:30 p.m. to 6 p.m. for this fun workshop on anal health and rectal microbicide research and advocacy.

Session 5: Imperial 9, Level 4. See ya there - show your rectal pride!


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 *Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,200 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

 *Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Monday, July 15, 2013

Adherence to rectal microbicide use among mainly ethnic minority young MSM: lessons from a 3-month placebo gel trial at three US sites [IAS 2013]

Oral paper presented by Alex Carballo-Diéguez at IAS 2013.

 

Abstract:

Background: Adherence to product use is the cornerstone of microbicide studies. This is the first study to assess how frequently mainly ethnic minority MSM, ages 18-30, with a history of unprotected receptive anal intercourse (RAI) in the prior year, would self-administer gel using a rectal-specific applicator prior to RAI in their everyday lives.

Methods: Recruitment took place in Boston, MA; Pittsburgh, PA, and San Juan, PR. Participants received 40 applicators prefilled with 4mL of hydroxyethylcellulose placebo gel that they could use over 12 weeks. They were asked to self-administer a dose within 90 minutes prior to RAI and report RAI and gel use at least weekly through an interactive voice response system (IVRS). At week 12, they responded to a Computer Assisted Self Interview (CASI) and underwent an in-depth interview. Participants were repeatedly counseled that the study focused on product adherence and that the gel would not protect against HIV.

Results: 124 MSM were enrolled (Mean age 23.1; 41% White, 40% Latino, 8% African American, 11% mixed/other). 95 participants completed the trial (18 were lost to follow up and 11 withdrew). Based on the IVRS, (n=94, 1 missing data), 88 participants had RAI (Median 10 occasions) using gel on 81.1% of occasions (SD 23.3, range 0-100). Based on CASI, (n=86, 9 refused to answer RAI question) 83 participants had RAI (Median 12 occasions) using gel on 81.7% of occasions (SD 26.7; 0-100). Based on CASI, 69% of men typically applied gel immediately before RAI; 40 inconsistent users gave as reasons not having gel with them (85%), forgetting to use it (48%), not wanting to use it (13%), partner refusal (10%) and gel messiness (10%).

Conclusions: Ethnically diverse young MSM with a history of unprotected RAI showed high adherence to gel use. Adherence to product use could potentially be enhanced by improving portability, facilitating the development of routines to counteract forgetfulness, and improving motivation and partner negotiation skills. Participant retention was challenging and needs further study. Two different self-report methods provided convergent results. Limitation: A product of known efficacy could have different uptake than the placebo used in this study.


Click for slides.

 
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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,200 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

*Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Monday, July 8, 2013

Meet Hailey Gilmore, A Friendly Rectal Microbicide Advocate

Find out a little about Hailey Gilmore in her interesting mini-bio, the latest in IRMA's "Meet a Friendly Rectal Microbicide Advocate" series on the IRMA website here.  Hailey is one of five new bios we are featuring.
 

Hailey Gilmore
San Francisco, California, USA

Hailey Gilmore studied international development in college and was always interested in sexual health promotion and education. While in school she interned at a local non-profit and developed a sex-ed workshop for youth in trade school. During this time she also became a volunteer HIV test counselor. This introduction to sexual health work opened the door for her current position as the Assistant Director of HIV Prevention Intervention Studies at Bridge HIV at the San Francisco Department of Public Health. She has been with Bridge HIV, supporting and coordinating clinical trials, for over four years.

Her organization conducts HIV prevention clinical trials testing HIV vaccines and pre-exposure prophylaxis (PrEP), and soon, rectal microbicides. Bridge HIV also studies behavioral interventions.

A little over a year ago, her organization was approached by the Microbicide Trials Network about conducting MTN-017, a phase II safety and acceptability study of rectally applied tenofovir gel among gay men, men who have sex with men, and transwomen in the US, Peru, Thailand, and South Africa. Hailey and her colleagues are incredibly excited for the MTN-017 launch later this year.

Hailey is also busy with the HPTN 069 study, or NEXT-PrEP, which is looking at the safety and tolerability of four daily oral regimens of PrEP. She is also analyzing qualitative data about people's motivations to take PrEP to better address advocacy strategies.

Hailey and her group will also soon be hosting a screening of "The Rectal Revolution is Here" in July to engage the San Francisco community on the topic of rectal microbicides.


Hailey would like to encourage IRMA to continue to find additional community allies to partner with - rectal microbicides are just too exciting to not talk about!

Thank you Hailey! 

------------------- *Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,100 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

*Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content. -------------------

Wednesday, May 29, 2013

Don't Upset This Rectal Microbicide Advocate!

by Mike Peters
IRMA Intern

A couple of weeks ago, I returned to Ohio for a weekend excursion.  The director of the Women's Studies program at my university informed me that I was named Graduate Student of the Year for Women's Studies and that there was a short awards ceremony that I should attend.  In preparation for this ceremony I was asked to dress nice, write a short bio of myself for the Dean of Liberal Arts to read, and to briefly say a few grateful words at the ceremony.

As excited and grateful as I was about this honor, I could not help but wonder what my interaction with the Dean of Liberal Arts would be like.  Perhaps some background information is necessary here.  My university is in Ohio, and Ohio, like so many other states, is facing a lot of economic issues in education.  During my last year on campus extreme budget cutbacks were made to Liberal Arts (while the basketball stadium and the Student Union were remodeled, and the basketball team was taking a trip to Italy).  Not only were these budget cuts devastating, but they were disturbing.  Six program directors, all women, were informed that they were being forced out of their directorships and required to teach additional classes.  These women, from fields that happened to focus on minority issues (Women's Studies, African and African-American Studies, International Studies, and so on), were to also be replaced  by a new dean of interdisciplinary studies that happened to be a white, heterosexual male as a cost-saving measure and way to increase course enrollment revenue.

Now, perhaps the male that would be replacing them had a strong background in interdisciplinary studies and could discuss minority issues with some level authority and expertise.  It was still utterly disturbing that these women were being removed from their leadership roles when they were all six some of the most respected educators on campus.  I suppose this is where my relationship with the Dean gets a little tricky.  In response to these budget cuts, I worked with three other graduate students as we led multiple protests and demonstrations of civil disobedience on campus – including flooding the Dean's office and taking over an intercom system to read The Vagina Monologues to the entire campus.  So my worry about standing with the Dean and listening to him comment on me was well-founded.

Excitedly, I wrote up a short bio of my educational background and my work new work with IRMA and sent it off to my program director.  On the trip there I worked tirelessly to remind myself to be respectful, not to worry, and to make sure I remembered to thank my various professors for their impact on my work.

On the day of the event my fiancé and I arrived at the auditorium and I was immediately informed that my bio had been edited, because it did not seem family-friendly enough as it used words like "anal", "rectal", and "sex".  Horrified by this reality, I was shuffled on stage and to my seat.  Given that I was being honored for Women's Studies I would be the last person receiving my award, since starting with a "W" the program always was at the end for liberal arts ceremonies, which gave me time to either get my visually-angered self calmed down or to let my anger at this injustice grow.  I chose the latter.

From my standpoint, and from my program director's viewpoint I might add, ignoring research and discussion because the word "anal" appears is not only ignorant, but is downright dangerous, as any member of IRMA certainly knows.  Besides, this is the work that I am doing with my degree, it ought to be celebrated.

So I sat… and sat… and sat.  And then the dean called me up to receive my award.  He read my censored bio as I smiled for the crowd.  Then he asked me to come to the podium to say a few grateful things:

"I'm really happy and thankful to be here today.  I'm also really happy that the Dean has given me a chance to talk about my work.  Right now I am working for IRMA, International Rectal Microbicide Advocates, to advocate for the development of rectal and vaginal microbicides in the global fight against HIV.  I'm very thankful that the education I received here has given me the ability to not be silent, and to actively advocate for proper sexual education as well as access to condoms and safe lubricants for vaginal and anal sex.  I mean let's be honest, HIV is still around and unprotected anal sex is major driver of this epidemic because we don't talk about it as actively as we should.  Thanks for hearing me out today."

Nobody freaked out.  The Dean shook my hand and I received my award.  No one walked out or ridiculed me; in fact a few folks told me that they admired my passion.  And in all seriousness, I was incredibly thankful to have the opportunity to speak about IRMA to people that likely had not heard of it before.  Though to be fair, I had better not ask the Dean for a recommendation letter any time soon.

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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,200 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

*Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Tuesday, May 7, 2013

Give Some LOVE to IRMA for Give OUT Day

Condoms are getting some help! 





Dear IRMA members and readers of this blog -

Give OUT Day shines a spotlight on organizations that empower LGBTQ communities across the country, and the AIDS Foundation of Chicago (AFC) is among these charities.

We’re using this campaign to highlight the next generation of HIV prevention: rectal microbicides. Though they’re still in development, these agents can be added to things like lubricants that will prevent the transmission of HIV, revolutionizing the way we protect ourselves and others. Condoms are getting some help!

This will greatly benefit gay and bisexual men, transgender individuals, and women because rectal microbicides are developed specifically for anal intercourse—a common human behavior. We need to expand the ways we protect ourselves against HIV, and rectal microbicides are quite promising. With the support of AFC’s global advocacy initiative—International Rectal Microbicide Advocates—scientists have achieved an enormous amount of progress, and we’re tremendously excited about the future.

You have an opportunity to support advocacy efforts that will be instrumental in making rectal microbicides a reality for all who need them.

Learn more by downloading this podcast on rectal microbicides, and visit our Give OUT page to make a contribution today.

Thanks,
Jim Pickett
Chair, International Rectal Microbicide Advocates


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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,200 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

*Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Monday, May 6, 2013

VIDEO: IRMA's Jim Pickett - Condoms Not Enough in HIV Fight

"Using condoms for your entire sexual life works for some people. And for others, it doesn't." 

Video via Be The Generation

IRMA chair Jim Pickett discusses the need for new ways to prevent HIV, like rectal microbicides.


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 *Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,200 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

 *Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Thursday, May 2, 2013

Facilitator's Guide for "The Rectal Revolution is Here" Video - English Version NOW Available

As many of our readers  know – in December IRMA, the Microbicide Trials Network, and Population Council launched the video “The Rectal Revolution is Here: An introduction to rectal microbicide clinical trials.” The 14-minute video includes researchers, advocates, and trial participants and discusses the need for rectal microbicides and the role of clinical trials in developing products that are safe and effective. It is available on YouTube in English, Spanish, and Thai and has been watched by several thousand viewers already.

The team has produced a facilitator’s guide to accompany the video, and the English version can be downloaded here.

The guide is meant to be used as a preparation tool for people leading community discussions, workshops, and/or recruitment sessions who will be showing the educational video. You will find simple, clear background information on rectal microbicide research and the clinical trial process as well as helpful hints on using the video.

We are still finalizing versions in Spanish and Thai – and will post them as soon as they are ready to go.

Many, many thanks to our partners at MTN and Population Council for their help and expertise with this guide, our Video Advisory Committee that provided invaluable feedback, our fabulous graphic designer from Toolbox, Inc., and to our intrepid Spanish and Thai translation teams!

If you would like an electronic copy of the video that you can keep on your computer or a flashdrive to be used for presentations, send a note to rectalmicro@gmail.com.

We hope you find this guide helpful!

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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,200 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

*Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Wednesday, April 17, 2013

African Common Position Paper Highlights Importance of Condom-Compatible Lubes and Rectal Microbicide Research

Our friends at AIDS Accountability International (AAI), in conjunction with The African Union Commission (AUC), recognised the need for greater African civil society organisation representation in the International Conference on Population Development (ICPD) process. So, tt was decided to create the African Common Position (ACP) on ICPD to reflect and include the perspectives, recommendations and expertise of African stakeholders.

The full ACP is available here. To sign on and endorse the Civil Society African Common Position please click here.

IRMA is excited to report that the need for safe, accessible, condom compatible lubricants as well as support for rectal microbicide research in Africa have been highlighted in the just completed African Common Position Paper (ACP) on ICPD. Our Project ARM - Africa for Rectal Microbicides effort is having an impact!

The specific sections on lube and rectal microbicides are as follows:
4.4.10. Recognise the need for further research into the role of anal and vaginal sexual lubricants for use as a tool to prevent HIV, STI’s and unplanned pregnancies, as well as its safety for users and compatibility with various other ingredients and condom varieties. Commit to making access to quality and affordable lubricants a reality for all people, as well as commit to funding for training and support for condom compatible lubricant use;

4.4.11. Train all health care workers, as well as procurement and head office ministry staff on new and evolving SRHR commodities especially with regard to HIV treatment and prevention technologies, this includes but is not limited to understanding the current vaginal and rectal micro-biocide and pre exposure prophylaxis fields in general and their specific programming implications for women and girls.

IRMA encourages you, or your organisation, to endorse the ACP. Click here to endorse.

Special thanks to IRMA member Tian Johsnon, one of the architects of Project ARM. His extraordinary leadership helped to make this happen. Kudos Tian!
Download the full African Common Position Paper here.

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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,200 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

*Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Wednesday, March 27, 2013

Now Playing - The Rectal Revolution is Here

video on rectal microbicide clinical trials

--- Now Playing ---  

"The Rectal Revolution is Here: An introduction to rectal microbicide clinical trials" on YouTube.


The vid, developed by IRMA, Microbicide Trials Network, and Population Council, is available in EnglishSpanish and Thai languages.

Watch to learn about the need for rectal microbicides, how clinical trials work, and the importance of volunteers in the effort to make safe, effective, acceptable and accessible new HIV prevention tools.

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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,200 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

  *Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Monday, March 4, 2013

IRMA Statement on VOICE Results

[Click here for the VOICE press release - "Daily HIV Prevention Approaches Didn’t Work for African Women in the VOICE Study" - from the Microbcide Trials Network]


IRMA, like the rest of new prevention technology researchers and advocates, is disappointed to learn that daily oral Truvada was not found to be an effective HIV intervention among the African women at risk for HIV who participated in the VOICE trial.

We applaud the efforts of the 5,029 women from South Africa, Zimbabwe, and Uganda who volunteered to participate in the VOICE trial. We also commend the Microbicide Trials Network and the National Institutes of Health for successfully executing this extraordinarily ambitious, important trial, and for contributing critical new information to the field.

Today at CROI 2013 we learned that the majority of women in the daily oral Truvada arm of VOICE were not taking their drugs regularly if at all. Rather than a biological explanation, it appears daily oral Truvada was not effective at preventing HIV among the women in the VOICE trial because the drug was not used regularly.

The results of VOICE indicate low adherence to all the drugs/regimens tested in the trial. There was also low adherence in the daily oral tenofovir and daily tenofovir gel arms. Both these arms were closed due to futility in late 2011 after separate reviews by the independent Data Safety and Monitoring Board. VOICE’s daily oral Truvada arm remained open until August 2012.

One of the biggest challenges the field faces is that of adherence. Clinical trials cannot show that a drug works to prevent HIV if trial participants do not take the drug. More must be done to accurately assess adherence during clinical trials in “real time”, and more must be done to develop HIV prevention interventions that people actually want to use, and like to use. But, we won’t be able to refine the drugs, the drug dosing strategies, and/or the drug delivery vehicles to make them more acceptable if trial participants are not adherent along the way.

Science is an iterative process. We are in the “car phone” phase of new prevention technologies - some of the drugs and dosing strategies are perhaps a little clunky. We all want to get to the “i-Phone” phase where we have interventions that are highly acceptable, and desired, but we won’t get there without going through the clunky phase first.

As the field moves forward, issues of recruitment are as important as adherence. Identifying potential trial participants who are most likely to be adherent during the trial is absolutely critical – and very challenging, as the way to achieve this is admittedly not clear.

The MTN-017 trial, a Phase II safety and acceptability study testing a reduced glycerin formulation of tenofovir gel, is getting ready to launch in the coming months. The study will enroll 186 gay men and transgender women at sites in Thailand, South Africa, Peru, and the United States, including Puerto Rico. It will be absolutely essential that MTN-017 volunteers take the study drugs as directed. If adherence is low during this trial, adequate amounts of safety data will not be collected, making it likely that efforts to develop tenofovir gel as a rectal microbicide will be halted permanently. Have no doubt, this would be a huge setback for rectal microbicide research, development, and advocacy efforts in general.

IRMA is very supportive of MTN-017’s inclusion of “real time” monitoring to assess adherence throughout the trial. This will allow investigators to understand and address challenges regarding adherence while the trial is underway, and will help participants make appropriate adjustments in “real time” to improve adherence outcomes. MTN-017 sites should also pay extra special attention to recruitment activities and work to engage and enroll individuals who are most likely to fully participate in the trial, and follow the various regimens being tested as directed.

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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,100 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

*Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Thursday, January 31, 2013

VIDEO: POZ on Location Captures 4 HOT Minutes on Rectal Microbicide Research

"The Bottom Line on Rectal Microbicide Research" was presented by IRMA's Jim Pickett at Gay Men's Health Crisis in NYC on January 23, 2013. POZ Magazine recorded the proceedings and produced this 4-minute highlight video, below. Check it out!

Click here to download Jim's presentation slides.

"The Rectal Revolution is Here" was screened as well. You can watch the 14-minute video describing rectal microbicide clinical trials on YouTube in English, Spanish, or Thai. It's an entertaining mix of live action and animation, and features a rectal microbicide trial participant who explains what the process was like, and why he chose to be in a prevention trial.



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  *Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,100 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

*Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Tuesday, January 29, 2013

Anal Sex at Christmas Eve Dinner


by Mike Peters
IRMA intern


Another Christmas season has come and gone and like most Americans, the season ended for me with a gym membership (that I will admittedly abandon before the end of January) and reflection on the often-awkward gathering of family members that Christmas-time usually drops at our feet.

Christmas-time was a busy season for us this year. Early in December I accepted an internship with IRMA and spent most of the month learning about rectal microbicides in preparation for my January start date. On December 10th, my boyfriend and I announced our engagement to family, friends, and facebook. This also meant that it was time for me to meet his family. Early in the morning on December 22nd, we began the long car trip from Chicago to rural Pennsylvania. As stressful as it was, first impressions went well and my fiancé and I began to prepare for the long string of rather conservative family members that slowly made their way towards his parents’ home. There is a rather significant age gap in between generations in his family so most of our time was spent in the basement with his brothers and sister-in-law.

However, Christmas Eve dinner required our presence upstairs. Family members began to fill in seats, someone said grace, and soon food was being passed around the table. People were beginning to be comfortable enough with me that they started making jokes about what this “skinny vegetarian” was actually going to be able to eat and I started to feel at ease. My fiancé was right, his family liked me and I could stop worrying. Conversation continued to flow in between mouthfuls of stuffing and eventually one of his uncles turned to me and asked, “So Mike, what is it that you do?”

“Oh, I’m a grad student,” I replied.

“And you also started an internship” My fiancé’s mother excitedly added.

I smiled, “yeah, I’m an intern with IRMA at the AIDS Foundation of Chicago”. My fiancé smiled, reminding me that this was going well and that he was happy my confidence was starting to show again.

“So what’s IRMA? What are you going to be doing?” his uncle asked.

“Well, I don’t know all the details yet, but I know that primarily we are advocating for proper lubricants and the development of rectal microbicides that help prevent HIV infections for men and women who receive anal sex. I also know that we’re focusing on international contexts as well.” They remained quiet, so I kept talking, “you know, especially in countries where anal sex is so taboo that people can’t even talk about it. We want to let people know that plenty of women and men, gay, straight, or anything in between have anal sex and it’s completely normal and natural. You know, we want to deconstruct that silence,” I paused to take a drink as my mouth was starting to feel dry “because silence, well you know, sucks. The HIV/AIDS infection rate is rising in so many groups all over the world and if we can’t even talk about anal sex, how can we even stop that trend?”

Then I realized that everyone was staring directly at me. Under the table, I could feel that my nervous fiancé was now gripping my leg. I looked around, smiled awkwardly, and took a drink.

Suddenly I was saved by my fiancé’s mother, “well… that’s… interesting,” she quickly turned to her niece, “so did your son enjoy his Christmas presents?” Conversation began to flow naturally again, my fiancé released his grip on my leg, and my awkward smile became more natural.

I sat back in my chair and observed the conversation. I just openly talked about anal sex to a group of strangers that are soon to be my family. Did I really just do that? As I looked down at the mashed potatoes on my plate I began to worry that I had blown my first (possibly only) chance to get to know these people before the wedding.

As I sat there, slowly eating my remaining food I began to think about why the conversation was so awkward. I mean, I mentioned anal sex to a group of strangers… at the damn Christmas dinner table. But then I began to think more about when it would be appropriate to talk about anal sex to strangers, or family, or friends, or all of the above. And then, some part of me felt like it was not at all appropriate to talk about anal sex. The sex that I have is deeply personal and private, why should I talk about it?

Then I remembered a particular quote that I have always held dear:

“In the cause of silence, each of us draws the face of her own fear – fear of contempt, of censure, or some judgment, or recognition, of challenge, of annihilation. But most of all, I think, we fear the visibility without which we cannot truly live… The fact that we are here and that I speak these words is an attempt to break that silence and bridge some of those differences between us, for it is not difference which immobilizes us, but silence. And there are so many silences to be broken.” (Taken from Audre Lorde’s Transformation of Silence into Language and Action)

Was Lorde likely talking directly about anal sex? Well, no. I’m willing to bet that that was not the case. Yet Lorde’s discussion of silence is a necessary part of the dialog for advocacy on anal health. If people are unwilling to speak openly about anal sex for any of the fears that Lorde mentions, then as activists we neglect to confront the struggle that we seek to deconstruct. If we stay silent, then we are passively accepting the status quo; a hegemonic status quo, rigidly entrenched in patriarchy and heterosexism that ignores the gaps in research and advocacy for proper anal health for men and women who engage in anal sex.

For us, silence is dangerous. Silence relegates us to the status of “outsider”, to “unnatural”, and to “immoral” – and most importantly, silence robs us of the ability to live our lives as whole human beings. Silence is a luxury, that as activists, we are not yet able to have. We should continue speaking in an attempt to bridge those differences and deconstruct that status quo. Yeah, it is frightening, but if activism has taught me anything, it is that a fear that petrifies us into silence serves to perpetuate oppression.

So as I sat there, slowly eating my remaining meal, I felt a sense of triumph within myself. I broke a silence, even if it was for a moment. And you know what? It was not that bad. My fiancé’s family apparently finds me fascinating, if not spirited, and his mother appreciates my “spunk”, whatever that means. Oh, and the wedding is still on.

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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,100 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

*Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Wednesday, January 2, 2013

GMHC presents: The Bottom Line on Rectal Microbicide Research - 1/23/13 in NYC

You are invited to a discussion and video presentation on rectal microbicide research and advocacy with IRMA and friends at Gay Men's Health Crisis in NYC, from 10am til noon on Wednesday, January 23, 2013.

View a special screening of the new video "The Rectal Revolution is Here: An introduction to rectal microbicide clinical trials."

Light refreshments will be provided. Event is FREE and open to the public.

For more details, click here for the fyer. Or click on the image below.



Click image to enlarge.

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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,100 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

  *Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Monday, December 17, 2012

Rectal microbicide research takes giant leap forward with groundbreaking educational video

HIV prevention organizations debut The Rectal Revolution Is Here: An Introduction to Rectal Microbicide Clinical Trials in advance of first-ever Phase II rectal microbicide trial

 


[Press Release]

International Rectal Microbicide Advocates (IRMA), the Population Council, and the Microbicide Trials Network (MTN) today released a collaborative video project called The Rectal Revolution Is Here: An Introduction to Rectal Microbicide Clinical Trials. The jointly produced video, the first of its kind, is designed to educate communities affected by HIV about rectal microbicide development and the importance of participating in clinical trials to help speed the search for new HIV prevention options.

"The Rectal Revolution will be an excellent tool for education and recruitment for MTN-017, the first-ever Phase II safety trial of a rectal microbicide planned to launch soon. The video will be particularly useful because it's not protocol-specific and can be used in future rectal microbicide trials as well," said Clare Collins, MTN associate director of communications and external relations and video co-producer.

"There is an engaging mixture of animation and live action with beautiful footage from Thailand, South Africa, Peru, and the United States," Collins continued, "and we showcase interviews with scientists, advocates, and an exceptional rectal microbicide trial participant, Rig Rush, who is both eloquent and entertaining as he shares his personal experience as a study volunteer."

Produced by Paw Print Productions of Cape Town, South Africa, the video is available for viewing now on YouTube in English, Spanish, and Thai.

"This educational video is a groundbreaking tool to recruit volunteers and educate public health leaders for what may be one of the most promising new methods to fight HIV," said co-producer Barbara Friedland, associate in the HIV and AIDS program at the Population Council. "It was developed through an intense consultative process to ensure accuracy and relevance to the communities where this video will be shown," she said.

"We wanted the video to be educational and engaging, and to encourage audiences to get involved in efforts to prevent HIV," Friedland continued."So we worked with an advisory committee comprising staff at rectal microbicide trial sites, scientists, advocates, and other community experts to develop the script. We screened 'rough cuts' of the video with 80 professionals in the field and pre-tested it in 13 focus group discussions with over 100 gay men and transgender women in Thailand, South Africa, Peru, and the United States," she said.

"The insights and wisdom these individuals shared with us were absolutely critical to shaping the final version of the video," said Friedland.

Major funding and support for the project was generously provided by the MAC AIDS Fund, the MTN, and the Population Council, through a grant from the Swedish Ministry of Foreign Affairs.

The video debut precedes the soon-to-be launched landmark study being conducted by MTN to test a reduced-glycerin formulation of tenofovir gel among gay men, other men who have sex with men, and transgender women for safety and acceptability. MTN-017 is not only the first-ever Phase II study of a rectal microbicide, it is also the first time rectal microbicide research is expanding outside the United States and going global, with sites in Thailand, South Africa, Peru, and Puerto Rico.

"IRMA and the Population Council enthusiastically support the start of MTN-017," said Jim Pickett, IRMA chair. "The 186 individuals who will volunteer for the trial will more than double the total number of people who have participated in rectal microbicide clinical trials to date. The study will mark a giant leap forward for the field of rectal microbicides and will set the stage for future large-scale efficacy trials," he said.

Pickett continued, "the day we have a safe, effective, and acceptable rectal microbicide as a much-needed HIV prevention option for people who engage in anal intercourse is within our sights—these are truly revolutionary times and we couldn't be more energized."

Learn more about the MTN-017 trial here.

###


IRMA, the Population Council, and MTN encourage HIV prevention advocates and community educators to screen The Rectal Revolution Is Here in their own workshops and sensitization sessions and to share it widely. To receive a copy of the video in English, Spanish, or Thai, please contact IRMA at rectalmicro@gmail.com.

Editorial notes:

Currently in development, microbicides are products (gels, lubricants, films) that could be applied in the rectum or the vagina to reduce the risk of HIV infection.

Unprotected anal intercourse is 10 to 20 times more likely to result in HIV infection compared to unprotected vaginal intercourse. Unprotected anal intercourse—a common human behavior—is a significant driver in the global HIV epidemic among gay men and transgender women as well as among heterosexuals.

IRMA, based at AIDS Foundation of Chicago, is a global network of more than 1,100 advocates, scientists, policy makers, and funders from six continents working together to advance a robust rectal microbicide research and development agenda. The "bottom line in HIV prevention," IRMA addresses the institutional, socio-cultural, and political stigma around the public health need for rectal microbicide research, and advocates to increase funding and commitment within this field of inquiry.

The Population Council confronts critical health and development issues—from stopping the spread of HIV to improving reproductive health and ensuring that young people lead full and productive lives. Through biomedical, social science, and public health research in 50 countries, we work with our partners to deliver solutions that lead to more effective policies, programs, and technologies that improve lives around the world. Established in 1952 and headquartered in New York, the Council is a nongovernmental, nonprofit organization governed by an international board of trustees.
 
The Microbicide Trials Network is a U.S. National Institutes of Health-funded worldwide collaborative clinical trials network focused on preventing the sexual transmission of HIV. Recognizing the importance of microbicides research to HIV/AIDS prevention, the National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health (NIH), established the Microbicide Trials Network (MTN) in 2006, with co-funding from the NIH’s National Institute of Mental Health and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The MTN brings together international investigators and community and industry partners devoted to reducing the sexual transmission of HIV through the development and evaluation of products used orally or applied topically.

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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,100 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

*Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Wednesday, November 7, 2012

Meet Annette Larkin, A Friendly Rectal Microbicide Advocate

Check out this interesting mini-bio of  Annette Larkin, the latest in IRMA's "Meet a Friendly Rectal Microbicide Advocate" series on the IRMA website here.  Annette is one of five new bios posted last week.



Annette Larkin
Alexandria, Virginia, USA


"It's possible that microcides will really find a home in the rectum, so to speak."

Annette is an IRMA advocate, a communications consultant and a guest lecturer at Georgetown University's grad school for communications. She is also the assistant editor of North Wind Magazine. Annette has additionally been working with CAMI - Coalition Advancing Multipurpose Innovations.

Besides being a fabulous IRMA advocate, Annette enjoys travelling, watching HBO's 'Girls', and hanging out with her gorgeous daughter Bella and boyfriend.

Annette first started engaging with IRMA because she found the group very dynamic and engaging and wanted to join in. Additionaly, she has workd with CONRAD, the developer of tenofovir gel for vaginal as well as rectal use.

Annette believes that rectal microbicides are important as a new HIV prevention technology because there seems to be an increase in the amount of people having anal sex, and lube is needed to maximize pleasure anyway. Her advice to IRMA is to keep believing in rectal microbicides!

Thank you, Annette, for all that you do!

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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,100 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

*Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Tuesday, November 6, 2012

Meet Jim Higginbotham, A Friendly Rectal Microbicide Advocate

Check out this interesting mini-bio of  Jim Higginbotham, the latest in IRMA's "Meet a Friendly Rectal Microbicide Advocate" series on the IRMA website here.  Jim is one of five new bios posted last week.




Jim Higginbotham
Birmingham, Alabama, USA


"I must continue to inspire others, especially the younger generation to carry the torch until the end of HIV."

Jim is the Community Educator for HIV Vaccines at the University of Alabama Birmingham - a site for a number of biomedical HIV prevention trials. He loves helping his community in the fight against HIV through education and counseling. During his spare time, Jim enjoys spending time at his family farm, kayaking, hiking, and camping.

Jim initially became involved with IRMA while attending Microbicide Trials Network meetings and conferences. He recruited men to participate in MTN 007, which was a rectal microbicide study that included the University of Alabama clinical research site. Jim believes that a combination of prevention strategies must be utilized to reduce the number of infections that continue to occur in the United States and around the world and asserts that "a rectal microbicide, marketed as a lubricant, could help achieve that goal because it would, in my opinion, be embraced by individuals who engage in anal sex as an easy way to protect themselves."

Jim advises IRMA to keep up the good work in helping to educate the community on the need for rectal microbicides. Currently, Jim is recruiting and screening individuals for the HVTN 505, a vaccine study.

Jim has lost many friends to HIV/AIDS... a loss which continues to inspire his involvement in the fight for prevention and treatments. Jim is the sole survivor of his original peer group of friends from his early twenties.

"If I had to point to one individual as an inspiration, I would have to say that person is Butch McKay, a great friend and tireless advocate for the community in the fight against HIV. Butch has inspired me more than anyone to do the work that I do."

Thank you, Jim, for all that you do!

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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,100 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

*Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Thursday, November 1, 2012

Meet Clare, A Friendly Rectal Microbicide Advocate

Check out this interesting mini-bio of  Clare Collins, the latest in IRMA's "Meet a Friendly Rectal Microbicide Advocate" series on the IRMA website here.  Clare  is one of five new bios posted October 30, 2012.



Clare Collins
Pittsburgh, Pennsylvania, USA


"I think rectal microbicides just make sense. The idea of a product that people might actually WANT to use to protect themselves against HIV is a no-brainer."

Clare is an Associate Director of Communications and External Relations at the Microbicide Trials Network (MTN), where she works to promote MTN's rectal microbicide agenda. She also works to strategize the best ways to communicate with others concerning complex health information around biomedical HIV prevention. After starting at the MTN in 2010, she got involved with IRMA through reaching out to IRMA chair Jim Pickett and believes rectal microbicides are a very important part of the HIV prevention research agenda.

Currently Clare is busy planning for the launch of the first-ever rectal microbicide Phase II trial (MTN 017), testing a reduced-glycerin version of tenofovir gel for safety and acceptability among gay men, other men who have sex with men, and transgender women at domestic and international sites. The first site is expected to open enrollment sometime in December 2012. Clare is also part of a team (including IRMA and Population Council) that developed a new educational video, "The Rectal Revolution is Here: An Introduction to Rectal Microbicide Clinical Trials," which will be launched at the same time MTN 017 starts. The video is 13 minutes long and will be available on YouTube. It features animation and live action, and has English, Spanish, and Thai versions.

Clare has been greatly influenced by her mother, who taught her valuable lessons about compassion and concern for others through her battle with cancer, including the necessity of universal access to health care. She is very excited about the future and looks forward to seeing the evolving research in this area.

Thank you, Clare, for all that you do!

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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,100 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

  *Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Wednesday, October 31, 2012

Meet Robert, A Friendly Rectal Microbicide Advocate

Check out this interesting mini-bio of  Robert Bucklew, the latest in IRMA's "Meet a Friendly Rectal Microbicide Advocate" series on the IRMA website here.  Robert is one of five new bios posted October 30, 2012.



Robert Bucklew
Cleveland, Ohio, USA


Robert is the Outreach Coordinator for the Case Western Reserve University AIDS Clinical Trial Unit. He works on a variety of HIV-related research issues, including treatment trials, microbicides, preventative vaccines and PrEP. Outside of work, Robert loves creating art.

Robert first got involved with IRMA through both Jim Pickett (IRMA chair) and his professional connection to the Microbicide Trials Network. He considers rectal microbicides to be of utmost importance in the field of biomedical HIV prevention, and think they will be especially effective if considered sex positive, and serve to enhance sexual pleasure as well as sexual health.

Currently, he is working to enroll gay and bisexual men and transgender women into a preventative HIV vaccine trial, HVTN 505. Additionally, he is working on a new PrEP trial, called HPTN 069. His efforts focus on populations at highest risk, where there is clear need for new prevention strategies.

Robert has been greatly influenced by the late Eric Rofes, whom he met at a Gay Men's Health Summit. He was enlightened by Eric's holistic, assets-based approach to gay male sexuality, both personally and professionally. Today, he considers himself a better man because of Eric's outlook.

Thank you, Robert, for all that you do!

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*Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,100 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

 *Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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Tuesday, October 30, 2012

Meet Jeton, A Friendly Rectal Microbicide Advocate

Check out this interesting mini-bio of  Jeton Ademaj, the latest in IRMA's "Meet a Friendly Rectal Microbicide Advocate" series on the IRMA website here.  Jeton is one of five new bios posted October 30, 2012.



Jeton Ademaj
New York City, USA

"Don't be afraid to own your sexuality, and don't be afraid to defend human nature from those who presume to redefine it."

For several years, Jeton remained unaware of IRMA's work, but became involved as communities began to really take notice of PrEP in 2011. IRMA's active listserv has provided a platform for a great deal of discussion and debate on the topic.

Jeton believes rectal microbicides are important because, in general, he believes that men dislike condoms and research has yet to create more pleasurable and desirable condoms to enhance usage. Through rectal (and vaginal) microbicides, receptive individuals can become empowered in preventing HIV/STI transmission, without having to get permission from the active partner to use protection.

Jeton advises IRMA to not be afraid to defend human nature, despite one's sexuality. He encourages IRMA to always publicize the work to further encourage researchers to become involved in IRMA's mission.

Currently, Jeton contributes as a voice of reason in certain POZ settings, and advocates for human rights through progressive politics.

Jeton loves spending time with his husband, reads various scientific and technological developments, and listens to live music. His biggest influences come from his family, his best friend, and his husband.

Thank you, Jeton, for all that you do!

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  *Join IRMA's robust, highly-active. moderated, global listserv addressing rectal microbicide research and advocacy as well as other interesting new HIV prevention technologies by contacting us at rectalmicro@gmail.com. Joining our listserv automatically makes you a member of IRMA - a network of more than 1,100 advocates, scientists, policy makers and funders from all over the world.

*Please look for us on Facebook: www.facebook.com/InternationalRectalMicrobicideAdvocates, and you can follow us on Twitter: @rectalmicro.

*Also, please note that shared news items from other sources posted on this blog do not necessarily mean IRMA has taken any position on the article's content.

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