Planning for pre-exposure prophylaxis to prevent HIV transmission: challenges and opportunities

via Journal of the International AIDS Society

Susan C Kim, Stephen Becker, Carl Dieffenbach, Blair S Hanewall, Catherine Hankins, Ying-Ru Lo, John W Mellors, Kevin O'Reilly, Lynn Paxton, Jason S Roffenbender, Mitchell Warren, Peter Piot and Mark R Dybul

Journal of the International AIDS Society 2010, 13:24doi:10.1186/1758-2652-13-24

Abstract:

There are currently several ongoing or planned trials evaluating the efficacy of pre-exposure prophylaxis (PrEP) as a preventative approach to reducing the transmission of HIV. PrEP may prove ineffective, demonstrate partial efficacy, or show high efficacy and have the potential to reduce HIV infection in a significant way. In addition to the trial results, it is important that issues related to delivery, implementation, and further research are also discussed. As a part of the ongoing discussion, in June 2009, the Bill & Melinda Gates Foundation sponsored a Planning for PrEP conference with stakeholders to review expected trial results, outline responsible educational approaches, and develop potential delivery and implementation strategies. The conference reinforced the need for continued and sustained dialogue to identify where PrEP implementation may fit best within a combination HIV prevention package. This paper identifies the key action points that emerged from the Planning for PrEP meeting.

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