"Rectal cells are more easily infected by HIV, a microbicide can make the most obvious difference to their vulnerability; it offers the most protection to the most easily-infected tissue cells, but makes less difference to less easily-infected tissue."
A number of presentations at the 2010 International Microbicides Conference in Pittsburgh concerned microbicide research using established classes of HIV drugs that have not been used as microbicides before.
Maraviroc had previously shown only modest anti-HIV activity as a microbicide. The current studies confirmed that its potency in preventing infection of cervical and penile tissue was relatively modest, unless the cells are already in an inflammatory state. The fact that, despite this, it protected monkeys from vaginal viral challenge suggests in might be a very potent rectal microbicide.
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