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via Aidsmap
A study using tenofovir and FTC (Truvada) to prevent rectal HIV infection in monkeys – so-called pre-exposure prophylaxis (PrEP) - has shown that it is as effective to take the medication up to three days before exposure as it is to take it a day before. Even taking Truvada a full week before exposure resulted in a considerable reduction in the risk of infection.
In contrast, taking the medication only two hours before exposure resulted in a smaller protective effect, possibly because intracellular concentrations of the drugs had not reached high enough levels.
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