Tuesday, September 9, 2008

Microbicide and PrEP potential for anal sex explored further in monkey studies

[via Aidsmap, by Gus Cairns]

There are still many unanswered questions about these two prevention technologies, and data from animal studies may provide important information that can help interpret the results of these studies, and design future studies too.

In animal studies, microbicide gels and oral pre-exposure prophylaxis with antiretroviral drugs appear to provide protection against anal exposure to the monkey equivalent of HIV, according to two reports published in August.

However the studies show that two drugs are probably better than one, that patchy adherence greatly increases the risk of infection, and that even where pre-exposure prophylaxis (PrEP) does not prevent infection, it might result in substantially slower progression of HIV disease due to a blunting of the viral load peak that occurs soon after infection.

Read the rest.

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