Can a Topical Microbicide Prevent Rectal HIV Transmission?

This Perspective - published on PLoS August 5, 2008, discusses the following study, also published in PLoS Medicine:

Cranage M, Sharpe S, Herrera C, Cope A, Dennis M, et al. (2008) Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel. PLoS Med 5(8): e157. doi:10.1371/journal.pmed.0050157

Martin Cranage and colleagues find that topical tenofovir gel can protect against rectal challenge with SIV in a macaque model, and can permit the induction of SIV-specific T cell responses.

Read the Perspective - Can a Topical Microbicide Prevent Rectal HIV Transmission?